|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing PRMT5 induces epithelial marker E-cadherin expression and down-regulates expression of mesenchymal markers including Vimentin, collagen I and β-catenin in PaTu8988 and SW1990 cells, whereas ectopic PRMT5 re-expression partially reverses these changes, indicating that PRMT5 promotes EMT in pancreatic cancer.
|
31851779 |
2020 |
|
Malignant neoplasm of pancreas
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing PRMT5 induces epithelial marker E-cadherin expression and down-regulates expression of mesenchymal markers including Vimentin, collagen I and β-catenin in PaTu8988 and SW1990 cells, whereas ectopic PRMT5 re-expression partially reverses these changes, indicating that PRMT5 promotes EMT in pancreatic cancer.
|
31851779 |
2020 |
|
Nasopharyngeal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, PSH upregulated the expression levels of E-cadherin and Claudin-1 while downregulating that of N-cadherin and vimentin on both NPC cell lines.
|
31850235 |
2019 |
|
Neoplasm Metastasis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, CARM1- and USP7-dependent LSD1 stabilization plays a key role in repressing E-cadherin and activating vimentin transcription through promoter H3K4me2 and H3K9me2 demethylation, respectively, which promotes invasion and metastasis of breast cancer cells.
|
31833203 |
2020 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, CARM1- and USP7-dependent LSD1 stabilization plays a key role in repressing E-cadherin and activating vimentin transcription through promoter H3K4me2 and H3K9me2 demethylation, respectively, which promotes invasion and metastasis of breast cancer cells.
|
31833203 |
2020 |
|
precancerous lesions
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Such enhancement of precancerous lesions and tumors was linked to a decreased expression of E-cadherin and β-catenin in parallel with an increase in Vimentin and N-cadherin, hallmark modifications of epithelial-mesenchymal transition.
|
31830481 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Vimentin has shown to be highly implicated in cancer initiation and progression.
|
31827725 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest a biomarker potential of VIM in NSCLC.
|
31827725 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Vimentin has shown to be highly implicated in cancer initiation and progression.
|
31827725 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, serum levels of VICM was not increased in late stages of NSCLC, but highly elevated in patients with COPD (<i>p</i> < 0.0001).
|
31827725 |
2019 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, TGM3 knockdown cells had increased E-cadherin levels and decreased vimentin levels, suggesting that TGM3 contributes to epithelial-mesenchymal transition (EMT) in HCC.
|
31822388 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, overexpression of DUSP5 inhibited the proliferation, migration and invasion accompanied with low level of MMP9 and Vimentin and high level of E-cadherin.
|
31821724 |
2020 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thirty-four autoantibodies were differentially expressed in RA patients compared with healthy controls; citrullinated vimentin was associated with treatment response.
|
31819160 |
2019 |
|
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, silencing ELFN1-AS1 significantly reduced the activation of extracellular signal-regulated protein kinase (Erk), up-regulated the protein expression of E-cadherin and down-regulated vimentin.
|
31814902 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mRNA expression of the epithelial-to-mesenchymal transition-associated genes was investigated, including E-cadherin (also termed CDH1), vimentin (VIM), discoidin domain receptor 1 (DDR1) and zinc finger E-box binding homeobox 1 (ZEB1) in female- and male-derived cancer cell lines by reverse transcription (RT)-PCR and the Broad-Novartis Cancer Cell Line Encyclopedia (CCLE) database analysis.
|
31807189 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The mRNA expression of the epithelial-to-mesenchymal transition-associated genes was investigated, including E-cadherin (also termed CDH1), vimentin (VIM), discoidin domain receptor 1 (DDR1) and zinc finger E-box binding homeobox 1 (ZEB1) in female- and male-derived cancer cell lines by reverse transcription (RT)-PCR and the Broad-Novartis Cancer Cell Line Encyclopedia (CCLE) database analysis.
|
31807189 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Vimentin(+) GFP(+) cells may also be a member of the cancer-associated stroma, originating from bone marrow.
|
31807176 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Vimentin(+) GFP(+) cells may also be a member of the cancer-associated stroma, originating from bone marrow.
|
31807176 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Transfection of miR-103 mimics into Tca8113 cells significantly upregulated miR-103 expression, decreased SALL4 mRNA and protein expression, inhibited proliferation and invasion of Tca8113 cell, downregulated MMP-9 and MMP-2 mRNA expression, increased E-cadherin, and decreased Vimentin protein expression (p<0.05).
|
31799662 |
2019 |
|
Neoplasm Metastasis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
lncRNA VIM-AS1 was overexpressed in PCa tissues and cell lines and promoted PCa proliferation and metastasis via EMT through regulating vimentin, which might provide a novel target for the diagnosis and therapy for PCa.
|
31786880 |
2020 |
|
Progression of prostate cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
lncRNA VIM-AS1 was overexpressed in PCa tissues and cell lines and promoted PCa proliferation and metastasis via EMT through regulating vimentin, which might provide a novel target for the diagnosis and therapy for PCa.
|
31786880 |
2020 |
|
Clear-cell metastatic renal cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kaplan Meier and ROC curve analysis identified three potential prognostic and diagnostic biomarkers (TGFB1, TIMP1 and VIM) for ccRCC from 15 hub genes.
|
31772671 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunohistiochemical analysis shown that the tumor cells were positive to vimentin and smooth muscle actin while negative to the S100 protein and desmin.
|
31764512 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer.
|
31761784 |
2019 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer.
|
31761784 |
2019 |